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Signatures of Aristolochic Acid Mutagenesis in Bladder Cancer

ABSTRACT: This study looks at signatures of Aristolochic Acid mutagenesis in bladder cancer, based on exome and whole genome sequencing data. Thirteen bladder tumors and their matched normal DNAs were sequenced on Illumina platforms. Among them eleven were exome sequenced and two were whole genome sequenced.

PROVIDER: EGAS00001000975 | EGA |

REPOSITORIES: EGA

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Mutation signatures implicate aristolochic acid in bladder cancer development.

Poon Song Ling SL Huang Mi Ni MN Choo Yang Y McPherson John R JR Yu Willie W Heng Hong Lee HL Gan Anna A Myint Swe Swe SS Siew Ee Yan EY Ler Lian Dee LD Ng Lay Guat LG Weng Wen-Hui WH Chuang Cheng-Keng CK Yuen John Sp JS Pang See-Tong ST Tan Patrick P Teh Bin Tean BT Rozen Steven G SG

Genome medicine 20150428 1

<h4>Background</h4>Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to bladder cancer.<h4>Methods</h4>Here, we investigated the involvement of AA-mutagenesis in bladder cancer by sequencing blad ...[more]

PMID: 26015808

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