Finnish population cohort genotyping B

ABSTRACT: The FINRISK cohorts comprise the respondents of representative, cross-sectional population surveys that are carried out every 5 years since 1972, to assess the risk factors of chronic diseases (e.g. CVD, diabetes, obesity, cancer) and health behavior in the working age population, in 3-5 large study areas of Finland. DNA samples were collected in the following survey years: 1987, 1992, 1997, 2002, 2007, and 2012. The MONICA and EHES (EU) procedures were applied in phenotype collection (cf. MORGAM) and a wide spectrum of laboratory tests was carried out from serum and plasma samples. Background information on socioeconomic status, medical history, diet, exercise, measured anthropometric measures, etc. was collected by questionnaires and during a clinical visit. Plasma/serum samples are still available for the 2002-2012 cohorts. The cohort sizes are 6000-8800 per survey. The cohorts have been followed up by linking them to the national hospital discharge register, causes-of-death register and cancer register. This project is an extension to previous efforts to build a catalogue of Finnish genome wide data on population-based Finsrisk samples with rich phenotypic characterisations and health registry link-up. These samples will extend the current Sequencing Initiative Suomi (SISu) samples with a combination of genotyping using Illumina HumanCoreExome array and SISu- based imputation. This will lead to high confidence common and low frequency variant catalogue. The project will be funded by Aarno Palotie’s remaining faculty funds complemented by Finnish funding from FIMM.

PROVIDER: EGAS00001001047 | EGA |

REPOSITORIES: EGA