Dataset Information

Preeclampsia InterPregGen Consortium: GWAS meta-analysis summary statistics for European fetal preeclampsia cases versus controls and GWAS genotype data for European fetal preeclampsia cases

ABSTRACT: Preeclampsia (PE) is a syndrome affecting pregnant mothers and fetus/babies characterised by hypertension and proteinuria, and is a leading cause of maternal and fetal death and of premature births worldwide. The InterPregGen Consortium was funded by a European Framework 7 (FP7) grant and grew out of the WTCCC3 GWAS comparing ~2000 UK PE mothers with ~6000 common UK controls. The EGAS00001001048 study is a GWAS meta-analysis of UK and Icelandic PE fetal (baby) cases versus controls and is one component of the InterPregGen FP7 project.

PROVIDER: EGAS00001001048 | EGA |

REPOSITORIES: EGA

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Publications

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

McGinnis Ralph R Steinthorsdottir Valgerdur V Williams Nicholas O NO Thorleifsson Gudmar G Shooter Scott S Hjartardottir Sigrun S Bumpstead Suzannah S Stefansdottir Lilja L Hildyard Lucy L Sigurdsson Jon K JK Kemp John P JP Silva Gabriela B GB Thomsen Liv Cecilie V LCV Jääskeläinen Tiina T Kajantie Eero E Chappell Sally S Kalsheker Noor N Moffett Ashley A Hiby Susan S Lee Wai Kwong WK Padmanabhan Sandosh S Simpson Nigel A B NAB Dolby Vivien A VA Staines-Urias Eleonora E Engel Stephanie M SM Haugan Anita A Trogstad Lill L Svyatova Gulnara G Zakhidova Nodira N Najmutdinova Dilbar D Dominiczak Anna F AF Gjessing Håkon K HK Casas Juan P JP Dudbridge Frank F Walker James J JJ Pipkin Fiona Broughton FB Thorsteinsdottir Unnur U Geirsson Reynir T RT Lawlor Debbie A DA Iversen Ann-Charlotte AC Magnus Per P Laivuori Hannele H Stefansson Kari K Morgan Linda L

Nature genetics 20170619 8

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility loc ...[more]

PMID: 28628106

Dataset Information

Preeclampsia InterPregGen Consortium: GWAS meta-analysis summary statistics for European fetal preeclampsia cases versus controls and GWAS genotype data for European fetal preeclampsia cases

Publications

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

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Preeclampsia InterPregGen Consortium: Large-scale GWAS meta-analysis of maternal preclampsia cases and controls from Europe and Central Asia. Plus extension of earlier European fetal preeclampsia GWAS meta-analysis (see EGAS00001001048) by adding Central Asian fetal preeclampsia cases and controls. Datasets provided under this study are GWAS meta-analysis summary statistics and individual level GWAS genotype data. Related InterPregGen Consortium data are also provided under studies EGAS00001000416 and EGAS00001000417 (whole genome sequence data for 100 unrelated Uzbeks and 100 unrelated Kazakhs) and EGAS00001001048 (European fetal preeclampsia GWAS summary statistics and genotype data
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