Dataset Information

Preeclampsia InterPregGen Consortium: Large-scale GWAS meta-analysis of maternal preclampsia cases and controls from Europe and Central Asia. Plus extension of earlier European fetal preeclampsia GWAS meta-analysis (see EGAS00001001048) by adding Central Asian fetal preeclampsia cases and controls. Datasets provided under this study are GWAS meta-analysis summary statistics and individual level GWAS genotype data. Related InterPregGen Consortium data are also provided under studies EGAS00001000416 and EGAS00001000417 (whole genome sequence data for 100 unrelated Uzbeks and 100 unrelated Kazakhs) and EGAS00001001048 (European fetal preeclampsia GWAS summary statistics and genotype data

ABSTRACT: Preeclampsia (PE) is a syndrome affecting pregnant mothers and fetus/babies characterised by hypertension and proteinuria, and is a leading cause of maternal and fetal death and of premature births worldwide. The InterPregGen Consortium was funded by a European Framework 7 (FP7) grant and grew out of the WTCCC3 GWAS comparing ~2000 UK PE mothers with ~6000 common UK controls. The EGAS00001001266 study includes two components the FP7 InterPregGen project: (a) GWAS case-control meta-analysis of maternal PE cases from Europe (UK, Iceland, Norway, Denmark, Finland) and Central Asia (Kazakhstan, Uzbekistan); (b) GWAS case-control meta-analysis of PE fetal (baby) cases from Europe (UK, Iceland, Norway, Denmark) and Central Asia (Kazakhstan, Uzbekistan)

PROVIDER: EGAS00001001266 | EGA |

REPOSITORIES: EGA

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Publications

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Steinthorsdottir Valgerdur V McGinnis Ralph R Williams Nicholas O NO Stefansdottir Lilja L Thorleifsson Gudmar G Shooter Scott S Fadista João J Sigurdsson Jon K JK Auro Kirsi M KM Berezina Galina G Borges Maria-Carolina MC Bumpstead Suzannah S Bybjerg-Grauholm Jonas J Colgiu Irina I Dolby Vivien A VA Dudbridge Frank F Engel Stephanie M SM Franklin Christopher S CS Frigge Michael L ML Frisbaek Yr Y Geirsson Reynir T RT Geller Frank F Gretarsdottir Solveig S Gudbjartsson Daniel F DF Harmon Quaker Q Hougaard David Michael DM Hegay Tatyana T Helgadottir Anna A Hjartardottir Sigrun S Jääskeläinen Tiina T Johannsdottir Hrefna H Jonsdottir Ingileif I Juliusdottir Thorhildur T Kalsheker Noor N Kasimov Abdumadjit A Kemp John P JP Kivinen Katja K Klungsøyr Kari K Lee Wai K WK Melbye Mads M Miedzybrodska Zosia Z Moffett Ashley A Najmutdinova Dilbar D Nishanova Firuza F Olafsdottir Thorunn T Perola Markus M Pipkin Fiona Broughton FB Poston Lucilla L Prescott Gordon G Saevarsdottir Saedis S Salimbayeva Damilya D Scaife Paula Juliet PJ Skotte Line L Staines-Urias Eleonora E Stefansson Olafur A OA Sørensen Karina Meden KM Thomsen Liv Cecilie Vestrheim LCV Tragante Vinicius V Trogstad Lill L Simpson Nigel A B NAB Aripova Tamara T Casas Juan P JP Dominiczak Anna F AF Walker James J JJ Thorsteinsdottir Unnur U Iversen Ann-Charlotte AC Feenstra Bjarke B Lawlor Deborah A DA Boyd Heather Allison HA Magnus Per P Laivuori Hannele H Zakhidova Nodira N Svyatova Gulnara G Stefansson Kari K Morgan Linda L

Nature communications 20201125 1

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q ...[more]

PMID: 33239696

Dataset Information

Publications

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

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