Genomics

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Blueprint RNAseq profile of purified plasma cells from multiple myeloma patients and tonsils of healthy donors

ABSTRACT: In the context of an epigenomic study of multiple myeloma, a have generated RNAseq profiles of purified plasma cells from 11 multiple myeloma patients and tonsils of 4 healthy donors

PROVIDER: EGAS00001001110 | EGA |

REPOSITORIES: EGA

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Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Agirre Xabier X   Castellano Giancarlo G   Pascual Marien M   Heath Simon S   Kulis Marta M   Segura Victor V   Bergmann Anke A   Esteve Anna A   Merkel Angelika A   Raineri Emanuele E   Agueda Lidia L   Blanc Julie J   Richardson David D   Clarke Laura L   Datta Avik A   Russiñol Nuria N   Queirós Ana C AC   Beekman Renée R   Rodríguez-Madoz Juan R JR   San José-Enériz Edurne E   Fang Fang F   Gutiérrez Norma C NC   García-Verdugo José M JM   Robson Michael I MI   Schirmer Eric C EC   Guruceaga Elisabeth E   Martens Joost H A JH   Gut Marta M   Calasanz Maria J MJ   Flicek Paul P   Siebert Reiner R   Campo Elías E   Miguel Jesús F San JF   Melnick Ari A   Stunnenberg Hendrik G HG   Gut Ivo G IG   Prosper Felipe F   Martín-Subero José I JI  

Genome research 20150202 4

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a highly heterogeneous pattern globally characterized by regional DNA hypermethylation embedded in extensive hypomethylation. In contrast to the widely reported DNA hypermethylation of promoter-associated CpG islands (CGIs) in cancer, hypermethylated sites in MM, as opposed to normal plasma cells, were located outside CpG islands and were u  ...[more]

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