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HumanMethylation450K data from Purified Plasma Cells of Monoclonal gammopathy of unknown significance and Multiple myeloma patients and Healthy donors

ABSTRACT: HumanMethylation450K data from Purified Plasma Cells of Monoclonal gammopathy of unknown significance and Multiple myeloma patients and Healthy donors

PROVIDER: EGAS00001000841 | EGA |

REPOSITORIES: EGA

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Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Agirre Xabier X Castellano Giancarlo G Pascual Marien M Heath Simon S Kulis Marta M Segura Victor V Bergmann Anke A Esteve Anna A Merkel Angelika A Raineri Emanuele E Agueda Lidia L Blanc Julie J Richardson David D Clarke Laura L Datta Avik A Russiñol Nuria N Queirós Ana C AC Beekman Renée R Rodríguez-Madoz Juan R JR San José-Enériz Edurne E Fang Fang F Gutiérrez Norma C NC García-Verdugo José M JM Robson Michael I MI Schirmer Eric C EC Guruceaga Elisabeth E Martens Joost H A JH Gut Marta M Calasanz Maria J MJ Flicek Paul P Siebert Reiner R Campo Elías E Miguel Jesús F San JF Melnick Ari A Stunnenberg Hendrik G HG Gut Ivo G IG Prosper Felipe F Martín-Subero José I JI

Genome research 20150202 4

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a highly heterogeneous pattern globally characterized by regional DNA hypermethylation embedded in extensive hypomethylation. In contrast to the widely reported DNA hypermethylation of promoter-associated CpG islands (CGIs) in cancer, hypermethylated sites in MM, as opposed to normal plasma cells, were located outside CpG islands and were u ...[more]

PMID: 25644835

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