Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001001170 | EGA |
REPOSITORIES: EGA
Sibley Christopher R CR Emmett Warren W Blazquez Lorea L Faro Ana A Haberman Nejc N Briese Michael M Trabzuni Daniah D Ryten Mina M Weale Michael E ME Hardy John J Modic Miha M Curk Tomaž T Wilson Stephen W SW Plagnol Vincent V Ule Jernej J
Nature 20150513 7552
It is generally believed that splicing removes introns as single units from precursor messenger RNA transcripts. However, some long Drosophila melanogaster introns contain a cryptic site, known as a recursive splice site (RS-site), that enables a multi-step process of intron removal termed recursive splicing. The extent to which recursive splicing occurs in other species and its mechanistic basis have not been examined. Here we identify highly conserved RS-sites in genes expressed in the mammali ...[more]