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Whole genome and transcriptome analysis of anaplastic thyroid carcinoma

ABSTRACT: Whole genome and transcriptome analysis of anaplastic thyroid carcinoma

PROVIDER: EGAS00001001214 | EGA |

REPOSITORIES: EGA

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The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.

Kasaian Katayoon K Wiseman Sam M SM Walker Blair A BA Schein Jacqueline E JE Zhao Yongjun Y Hirst Martin M Moore Richard A RA Mungall Andrew J AJ Marra Marco A MA Jones Steven J M SJ

BMC cancer 20151218

<h4>Background</h4>Anaplastic thyroid carcinoma is the most undifferentiated form of thyroid cancer and one of the deadliest of all adult solid malignancies. Here we report the first genomic and transcriptomic profile of anaplastic thyroid cancer including those of several unique cell lines and outline novel potential drivers of malignancy and targets of therapy.<h4>Methods</h4>We describe whole genomic and transcriptomic profiles of 1 primary anaplastic thyroid tumor and 3 authenticated cell li ...[more]

PMID: 26680454

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