Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001001306 | EGA |
REPOSITORIES: EGA
Puente Xose S XS Beà Silvia S Valdés-Mas Rafael R Villamor Neus N Gutiérrez-Abril Jesús J Martín-Subero José I JI Munar Marta M Rubio-Pérez Carlota C Jares Pedro P Aymerich Marta M Baumann Tycho T Beekman Renée R Belver Laura L Carrio Anna A Castellano Giancarlo G Clot Guillem G Colado Enrique E Colomer Dolors D Costa Dolors D Delgado Julio J Enjuanes Anna A Estivill Xavier X Ferrando Adolfo A AA Gelpí Josep L JL González Blanca B González Santiago S González Marcos M Gut Marta M Hernández-Rivas Jesús M JM López-Guerra Mónica M Martín-García David D Navarro Alba A Nicolás Pilar P Orozco Modesto M Payer Ángel R ÁR Pinyol Magda M Pisano David G DG Puente Diana A DA Queirós Ana C AC Quesada Víctor V Romeo-Casabona Carlos M CM Royo Cristina C Royo Romina R Rozman María M Russiñol Nuria N Salaverría Itziar I Stamatopoulos Kostas K Stunnenberg Hendrik G HG Tamborero David D Terol María J MJ Valencia Alfonso A López-Bigas Nuria N Torrents David D Gut Ivo I López-Guillermo Armando A López-Otín Carlos C Campo Elías E
Nature 20150722 7574
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the ...[more]