Genomics

Dataset Information

0

Genetic landscape of relapsed DLBCL


ABSTRACT: Diffuse large B-cell lymphoma is a heterogenous malignancy that can arise de novo or can result from histologic transformation from indolent lymphomas. Considerable sequencing effort has been placed on determining the mutations that are common at the time of diagnosis in DLBCL but little is known about the nature of relapsed disease. We have sequenced tumour and matched normal exomes of 38 rrDLBCL patients including 25 de novo DLBCLs and 13 transformed lymphomas to identify somatic mutations and copy number alterations associated with relapse.

PROVIDER: EGAS00001001553 | EGA |

REPOSITORIES: EGA

altmetric image

Publications

Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.

Morin Ryan D RD   Assouline Sarit S   Alcaide Miguel M   Mohajeri Arezoo A   Johnston Rebecca L RL   Chong Lauren L   Grewal Jasleen J   Yu Stephen S   Fornika Daniel D   Bushell Kevin K   Nielsen Torsten Holm TH   Petrogiannis-Haliotis Tina T   Crump Michael M   Tosikyan Axel A   Grande Bruno M BM   MacDonald David D   Rousseau Caroline C   Bayat Maryam M   Sesques Pierre P   Froment Remi R   Albuquerque Marco M   Monczak Yury Y   Oros Kathleen Klein KK   Greenwood Celia C   Riazalhosseini Yasser Y   Arseneault Madeleine M   Camlioglu Errol E   Constantin André A   Pan-Hammarstrom Qiang Q   Peng Roujun R   Mann Koren K KK   Johnson Nathalie A NA  

Clinical cancer research : an official journal of the American Association for Cancer Research 20151208 9


<h4>Purpose</h4>Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of patients, and yet little is known about its biology.<h4>Experimental design</h4>Using exome sequencing, we characterized the mutation profiles of 38 rrDLBCL biopsies obtained at the time of progression after immunochemotherapy. To identify genes that may be associated with relapse, we compared the mutation frequency in samples obtained at relapse to an unrelated cohort of 138 diagnostic DLBCLs and s  ...[more]

Similar Datasets

2014-01-27 | E-GEOD-42906 | biostudies-arrayexpress
2014-01-27 | GSE42906 | GEO
2024-09-30 | GSE252690 | GEO
2013-01-23 | E-GEOD-43606 | biostudies-arrayexpress
2013-01-23 | GSE43606 | GEO
2016-10-12 | GSE80351 | GEO
2022-07-01 | GSE179689 | GEO
2013-05-13 | E-GEOD-45982 | biostudies-arrayexpress
2012-10-04 | GSE41315 | GEO
2017-04-01 | GSE92676 | GEO