Genomics

Dataset Information

0

Molecular characterization of endothelial cells under conditions associated with hematopoietic niche formation in humans


ABSTRACT: Using a combinatory approach of cell purification and transcriptomics, we identify a subset of endoglin-expressing endothelial cells enriched in human bone marrow during fetal ontogeny and regeneration after chemotherapeutic injury. Comprehensive transcriptional characterization by massive parallel RNA sequencing of these cells revealed a remarkable phenotypic and molecular similarity to murine H endothelium as well as activation of pathways and angiocrine factors implicated in hematopoiesis, osteogenesis and angiogenesis.

PROVIDER: EGAS00001002736 | EGA |

REPOSITORIES: EGA

Similar Datasets

2024-05-17 | PXD051130 | Pride
| S-EPMC10403211 | biostudies-literature
2024-05-16 | GSE263388 | GEO
2024-05-16 | GSE265836 | GEO
2024-05-16 | GSE263389 | GEO
2024-05-16 | GSE263390 | GEO
2023-08-06 | GSE164787 | GEO
2022-03-03 | GSE171672 | GEO
2023-03-21 | GSE206589 | GEO
2024-11-09 | GSE278987 | GEO