Dataset Information

BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology)

ABSTRACT: The BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology) study is an ongoing longitudinal, population-based prospective birth cohort including 4,089 children born between 1994 and 1996 in Stockholm, Sweden. The cohort was initially designed to study risk factors for asthma, allergic diseases and lung function in childhood, and to study factors of importance for prognosis at already established disease.Questionnaires on respiratory symptoms and medication were answered at age of 1, 2, 4, 8 and 16 years. Response rates ranged from 96-82% at each occasion with very minor selection bias over the years. Exposure to air pollutants and other environmental factors has been mapped since birth.At the 8 and 16 year follow-up, spirometry and FeNO measurements were performed and at the latter, impulse oscillometry was measured. Blood samples (including plasma) from around 2,500 children were taken at 4, 8 and 16 years and have been analyzed for different IgE-ab and biomarkers. Genome-wide genetic, global methylation and transcriptomic data exist on a subset of the children.

PROVIDER: EGAS00001002746 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Publications

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Xu Cheng-Jian CJ Söderhäll Cilla C Bustamante Mariona M Baïz Nour N Gruzieva Olena O Gehring Ulrike U Mason Dan D Chatzi Leda L Basterrechea Mikel M Llop Sabrina S Torrent Maties M Forastiere Francesco F Fantini Maria Pia MP Carlsen Karin C Lødrup KCL Haahtela Tari T Morin Andréanne A Kerkhof Marjan M Merid Simon Kebede SK van Rijkom Bianca B Jankipersadsing Soesma A SA Bonder Marc Jan MJ Ballereau Stephane S Vermeulen Cornelis J CJ Aguirre-Gamboa Raul R de Jongste Johan C JC Smit Henriette A HA Kumar Ashish A Pershagen Göran G Guerra Stefano S Garcia-Aymerich Judith J Greco Dario D Reinius Lovisa L McEachan Rosemary R C RRC Azad Raf R Hovland Vegard V Mowinckel Petter P Alenius Harri H Fyhrquist Nanna N Lemonnier Nathanaël N Pellet Johann J Auffray Charles C van der Vlies Pieter P van Diemen Cleo C CC Li Yang Y Wijmenga Cisca C Netea Mihai G MG Moffatt Miriam F MF Cookson William O C M WOCM Anto Josep M JM Bousquet Jean J Laatikainen Tiina T Laprise Catherine C Carlsen Kai-Håkon KH Gori Davide D Porta Daniela D Iñiguez Carmen C Bilbao Jose Ramon JR Kogevinas Manolis M Wright John J Brunekreef Bert B Kere Juha J Nawijn Martijn C MC Annesi-Maesano Isabella I Sunyer Jordi J Melén Erik E Koppelman Gerard H GH

The Lancet. Respiratory medicine 20180226 5

<h4>Background</h4>DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma.<h4>Methods</h4>We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blo ...[more]

PMID: 29496485

Similar Datasets

Project description:Background: The prevalence of individuals allergic to latex, exhibiting cross-hypersensitivity with plant-derived food has been frequently reported as the so-called latex-fruit syndrome. Nonetheless, molecular mechanisms underlying allergy to latex and/or fruit are poorly understood. Objective: The aims of this study were to identify candidate genes that may be associated with the pathogenesis of allergy to latex and /or vegetable food, and to assess if similar molecular pathways are involved in both types of hypersensitivity. Methods: DNA microarray analysis was performed to screen the molecular profiles of peripheral blood mononuclear cells isolated from patients with allergy to latex, to fruit, or with latex-fruit syndrome, and from control healthy subjects. Results: Gene expression profiling identified an overlapping dataset of genes commonly regulated in all the atopic patients enrolled in this study, suggesting that similar molecular mechanisms are involved in the pathogenesis of allergy to the fruit and /or latex. Several regulators of the innate and acquired immunity reported to polarize the immunological response towards a Th2-mediated immune response were overexpressed in patients. Furthermore, evidences suggested that T regulatory cell expression might be defective in allergic patients, as a consequence of a dysregulation of some inflammatory cytokines. Finally, several transcription factors that may be responsible for the Th1/Th2 imbalance were modulated in allergic patients. Conclusion and clinical implications: This study identified relevant genes that may help to elucidate the molecular mechanisms underlying allergic disease. Knowledges of critical targets, along with transcription factors regulating gene activity may facilitate the development of new therapies. Experiment Overall Design: This study aimed at the understanding of the molecular pathways involved in allergy to latex and fruit. As latex and vegetable food allergens cross-react, it could be hypothesized that similar pathways are involved in both types of hypersensitivity. Experiment Overall Design: For this purpose, patients allergic to latex (n=6), allergic to vegetable food (n=5), or suffering from latex-fruit syndrome (n=6) were enrolled from the Unit of Allergy of the Gemelli Hospital of Rome. Moreover, 4 healthy volunteers were added to this study. Five ml of blood were harvested from each individual, and PBMCs were isolated on ficoll gradient. Following sample preparation (as recommended by the manufacturer), each sample was hybridized on Affymetrix human focus array. Data were processed with Affymetrix MAS 5.0 software and averaged intensity of signals from biological replicates were calculated for further analysis. Experiment Overall Design: The CEL files for this study were lost in a computer crash.

Dataset Information

BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology)

Publications

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets