Project description:This study includes RNAseq data of lesional and autologous non-lesional skin from patients with non-communicable inflammatory skin diseases, including psoriasis, nummular eczema and atopic dermatitis.

2024-06-20 | GSE154200 | GEO

Cutaneous T cells promote distinct transcriptional programs in human skin structural cells associated with inflammatory disease

Project description:T cells coordinate with structural cells in the skin to promote appropriate inflammatory responses and subsequent restoration of barrier integrity following insult. Single cell studies of human skin have defined an assortment of transcriptionally distinct structural cell populations in healthy tissue and identified inflammatory disease-associated changes in epithelial keratinocytes and dermal fibroblasts. Cutaneous T lymphocyte activity is implicated in the development of inflammatory skin disease, but the mechanisms by which T cells promote disease-associated changes in the skin remain unclear. We show that distinct subsets of circulating and resident CD4+ cutaneous T cells promote a diverse array of transcriptional outcomes in human keratinocytes and fibroblasts. Using these in vitro generated transcriptional signatures, we identify T cell-dependent gene modules associated with inflammatory skin diseases in vivo, such as a set of Thelper17 cell-induced genes in keratinocytes that are enriched in the skin of patients with psoriasis and normalized in response to anti-IL-17 therapy. Thus, we present an approach to define the immune-dependent gene networks of skin structural cells, which we use to study the T cell contribution to inflammatory skin disease and response to anti-cytokine therapy.

2025-04-15 | GSE272623 | GEO

E-GEOD-18781

Project description:Gene Expression in Inflammatory Diseases

2025-01-24 | E-GEOD-18781 | ExpressionAtlas

Spatial transcriptomics landscape of non-communicable inflammatory skin diseases

Project description:Spatial transcriptomics landscape of non-communicable inflammatory skin diseases

| PRJNA850422 | ENA

scRNA-seq of embryonic skin development (developmental time series in full-thickness dorsal skin of mouse embryos)

Project description:In this study, we analysed early embryonic skin development (mus musculus; C57BL/6J) at the transcriptional level. Major questions concerned the cell type composition of early embryonic skin, and the emergence of transcriptional heterogeneity among epithelial and stromal precursor cells. Cells were isolated from embryonic dorsal skin and randomly sequenced (scRNA-Seq using 10X Genomics v2) without any cell sorting. Data from three embryonic time points (E12.5, E13.5, and E14.5) was integrated and compared to obtain a better understanding of the dynamics of early skin development.

2023-07-16 | E-MTAB-11920 | biostudies-arrayexpress

Immune Modules to guide Diagnosis and Personalized Treatment of Inflammatory Skin Diseases

Project description:we profiled the inflammatory transcriptome of skin lesions from patients with inflammatory skin diseases

2024-11-08 | GSE280220 | GEO

Transcriptomic profiling of keratinocytes isolated from patients with rare inflammatory skin disorders

Project description:Inflammatory skin diseases, including inflammatory linear verrucous epidermal naevus (ILVEN) and psoriasis, are known to collectively be hyperproliferative. We endeavoured to do a transcriptional comparative study on patient and control keratinocytes to uncover a final druggable common pathway for those disorders.

2023-09-01 | E-MTAB-12925 | biostudies-arrayexpress

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