Genomics

Dataset Information

0

Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors


ABSTRACT: Gatekeeper mutations are identified in only 50% of the cases at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors (TKIs). Circulating tumor cells (CTCs) are relevant tools to identify additional resistance mechanisms and can be sequenced at the single-cell level. Here, we provide in-depth investigation of copy number alteration (CNA) heterogeneity in phenotypically characterized CTCs at resistance to ALK-TKIs in ALK-positive non-small cell lung cancer.

PROVIDER: EGAS00001005301 | EGA |

REPOSITORIES: EGA

Similar Datasets

2022-08-14 | GSE77764 | GEO
2017-02-17 | GSE94809 | GEO
2019-12-31 | GSE117181 | GEO
2019-12-15 | E-MTAB-8563 | biostudies-arrayexpress
2019-12-22 | E-MTAB-8590 | biostudies-arrayexpress
2023-08-09 | GSE223779 | GEO
2018-05-28 | GSE81482 | GEO
| EGAS00001000082 | EGA
2018-05-28 | GSE97646 | GEO
2018-05-28 | GSE81261 | GEO