Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients
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ABSTRACT: In this study, we analyzed the lymphocyte response to anti-LAG3+anti-PD1 treatment (relatilimab+nivolumab, phase I, NCT01968109) in prior and 4- and 12-week posttherapy blood samples from 40 metastatic melanoma patients using scRNA+TCRαβ-seq, flow cytometry, TCRβ-seq, and serum protein profiling together with ex vivo functional validations.
PROVIDER: EGAS00001005580 | EGA |
REPOSITORIES: EGA
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