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Enhanced detection of MRD with cfDNA Fragmentomics.

ABSTRACT: The circulating tumor DNA (ctDNA) mutation-based approach shows limited performance in minimal residual disease (MRD) detection, especially for landmark MRD detection at an early-stage cancer after surgery. Here, we describe a cell-free DNA (cfDNA) fragmentomics-based method in MRD detection of resectable non-small cell lung cancer using whole genome sequencing, and the cfDNA-fragmentomics showed a great sensitivity in predicting prognosis.

PROVIDER: EGAS00001007192 | EGA |

REPOSITORIES: EGA

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