Genomics

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Finding structural variation and functional consequences from primary acute myeloid leukemia cells with complex karyotype (CK-AML) at the single-cell level


ABSTRACT: In this study, we aimed to extend our understanding of the intra-tumor heterogeneity evolution in CK-AML and exemplify the translational relevance of single-cell clonal evolution analyses. To achieve this, we leveraged two single-cell multi-omics frameworks, scNOVA and CITE-seq, to link genotype, epigenome and phenotype of four primary CK-AML patients, and coupled this with functional xenotransplantation assays.

PROVIDER: EGAS00001007436 | EGA |

REPOSITORIES: EGA

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