Dataset Information
National Human Genome Research Institute Tumor Sequencing Project (TSP) - Lung Adenocarcinoma
Ontology highlight
ABSTRACT: The Tumor Sequencing Project (TSP) Consortium is a collaboration among participants at the Baylor College of Medicine Human Genome
Sequencing Center, the Broad Institute Genome Sequencing Platform, the Dana Farber Cancer Institute, the Memorial Sloan-Kettering Cancer
Center, the Genome Sequencing Center and Siteman Cancer Center at Washington University, the M.D. Anderson Cancer Center and the
University of Michigan Medical Center. The TSP Part A will pilot approaches to large-scale identification of genomic changes in tumors
by sequencing the exonic regions of 623 genes in 188 specimens of adenocarcinoma of the lung, as well as using high density SNP
genotyping arrays for high resolution identification of changes in chromosomal copy number. The TSP Part B will pilot approaches to tumor characterization of lung adenocarcinoma samples using next-generation sequencing
technologies and benchmark those results against Part A data generated with ABI3730 instruments.
OTHER RELATED OMICS DATASETS IN: PRJNA74925PRJNA41441PRJNA112737
PROVIDER: phs000144.v1.p1 | EGA |
REPOSITORIES: EGA
Publications
Somatic mutations affect key pathways in lung adenocarcinoma.
Nature 20081001 7216
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus ar ...[more]
