Dataset Information
Genome Wide Association Studies in ECOG 2903 Trial
Ontology highlight
ABSTRACT: The ECOG 2997 trial was a randomized controlled trial for patients with previously untreated CLL comparing fludarabine monotherapy to the combination of fludarabine and cyclophosphamide. The initial clinical findings of this study were published in the Journal of Clinical Oncology in 2007 (JCO 25:793-8). Additional laboratory studies have also published (JCO 25:799-804).
PROVIDER: phs000621.v1.p1 | EGA |
REPOSITORIES: EGA
Publications
Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070205 7
<h4>Purpose</h4>The combination of fludarabine and cyclophosphamide is an effective regimen for patients with chronic lymphocytic leukemia (CLL). However, it may be accompanied by increased toxicity compared with fludarabine alone. E2997 is a phase III randomized Intergroup trial comparing fludarabine and cyclophosphamide (FC arm) versus fludarabine (F arm) alone in patients receiving their first chemotherapy regimen for CLL.<h4>Patients and methods</h4>Symptomatic, previously untreated patients ...[more]
