Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic and environmental factors contributing to Parkinsons disease: a case-control study

ABSTRACT: A case-control study was conducted with Parkinson's Disease (PD) patients healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD.

INSTRUMENT(S): -

ORGANISM(S): Homo Sapiens

SUBMITTER: The Cyprus Institute of Neurology and Genetics

PROVIDER: PRJEB32182 | EVA | 2019-04-16

REPOSITORIES: EVA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	andreadata.vcf.gz	Vcf
	andreadata.vcf.gz.tbi	Vcf

Items per page:

1 - 2 of 2

Similar Datasets

Case Control Study to Identify Modifiable Risk Factors for Colorectal and Breast Cancer in Nigeria

Project description:This project is a case-control study which seeks to identify modifiable risk factors for breast and colorectal cancer in Nigeria. Both cases and controls will be required to complete a risk factor questionnaire which contains information about their diet, physical activity, past medical history and life style factors. They will also be required to provide information on their body composition through the use of a bioimpedance machine which measures the body mass index, fat and total body water percentage. Based on the existing ARGO platform where a current colorectal cancer study is going on, approximately 400 patients with a prior diagnosis or a new diagnosis will be recruited into this study. Comparatively, we will select our 400 controls from two groups of participants who are free of cancer and gastrointestinal diseases.

| 2389671 | ecrin-mdr-crc

Ovarian Tumor Risk and Environmental and Genetic Factors

Project description:Ovarian Tumor Risk and Environmental and Genetic Factors

| PRJNA302695 | ENA

Copy number variation analysis on a non-Hodgkin lymphoma case-control study identifies an 11q25 duplication associated with diffuse large B-cell lymphoma

Project description:Recent GWAS have identified several susceptibility loci for NHL. Despite these successes, much of the heritable variation in NHL risk remains to be explained. Common copy-number variants are important genomic sources of variability, and hence a potential source to explain part of this missing heritability. In this study, we carried out a CNV analysis using GWAS data from 681 NHL cases and 749 controls to explore the relationship between common structural variation and lymphoma susceptibility. Here we found a novel association with diffuse large B-cell lymphoma (DLBCL) risk involving a partial duplication of the C-terminus region of the LOC283177 long non-coding RNA that was further validated by quantitative PCR. For chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), known somatic deletions were identified on chromosomes 13q14, 11q22-23, 14q32 and 22q11.22. Our study shows that GWAS data can be used to identify germline CNVs associated with disease risk for DLBCL and somatic CNVs for CLL/SLL. We performed a genome-wide CNV analysis of 681 NHL cases and 749 controls from the San Francisco Bay Area, genotyped using the Illumina HumanCNV370-Duo BeadChip array. Signal intensity data in the form of log R ratio (LRR) and B allele frequency (BAF) values were obtained directly from the Beadstudio software. Quality control filtering was used to exclude unreliable samples, resulting in a final dataset of 619 NHL cases (205 FL, 242 DLBCL, 172 CLL/SLL) and 730 controls.

2014-09-23 | E-GEOD-58718 | biostudies-arrayexpress

Genetic and Environmental Risk Factors for Cocaine Addiction (COCCAINE)

Project description:Genetic and Environmental Risk Factors for Cocaine Addiction (COCCAINE)

| PRJNA532957 | ENA

Genetic and Environmental Risk Factors for Hemorrhagic Stroke study

Project description:Genetic and Environmental Risk Factors for Hemorrhagic Stroke study

| PRJNA276717 | ENA

Genetic and Environmental Risk Factors for Cocaine Addiction (COCCAINE)

Project description:Genetic and Environmental Risk Factors for Cocaine Addiction (COCCAINE)

| PRJNA532956 | ENA

Copy number variation analysis on a non-Hodgkin lymphoma case-control study identifies an 11q25 duplication associated with diffuse large B-cell lymphoma

2014-09-23 | GSE58718 | GEO

CIDR/NICHD GWAS of Trisomy 21: Risk Factors for Chromosome Non-disjunction

Project description:CIDR/NICHD GWAS of Trisomy 21: Risk Factors for Chromosome Non-disjunction

| PRJNA238609 | ENA

An integrated approach to identify environmental modulators of genetic risk factors for complex traits

Project description:Complex traits and diseases can be influenced by both genetics and environment. However, given the large number of environmental stimuli and power challenges for gene-by-environment testing, it remains a critical challenge to identify and prioritize specific disease-relevant environmental exposures. We propose a novel framework for leveraging signals from transcriptional responses to environmental perturbations to identify disease-relevant perturbations that can modulate genetic risk for complex traits and inform the functions of genetic variants associated with complex traits. We perturbed human skeletal muscle, fat, and liver relevant cell lines with 21 perturbations affecting insulin resistance, glucose homeostasis, and metabolic regulation in humans and identified thousands of environmentally responsive genes. By combining these data with GWAS from 31 distinct polygenic traits, we show that the heritability of multiple traits is enriched in regions surrounding genes responsive to specific perturbations and, further, that environmentally responsive genes are enriched for associations with specific diseases and phenotypes from the GWAS catalog. Overall, we demonstrate the advantages of large-scale characterization of transcriptional changes in diversely stimulated and pathologically relevant cells to identify disease-relevant perturbations.

2021-07-09 | GSE179347 | GEO

S3 Swedish schizophrenia case-control study

Project description:Genome-wide case-control association study in Sweden, with the aim to study the genetic basis of schizophrenia risk, disease severity and treatment resistance, as well as the interplay with environmental risk factors. The study cohort includes array-based data from whole blood-DNA. Population-based sampling was used to recruit cases with schizophrenia, based on data from the Swedish national patient register, as well as controls who had never been hospitalized for schizophrenia or bipolar disorder.

| EGAS00001006772 | EGA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data