Transcriptomics

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Genome-wide gene expression analysis of hNAC1-dependent time course rescue of Nac1 null abnormal reprogrammed cells


ABSTRACT: In this study, we dissected the functional contribution of NAC1 in establishing pluripotency during somatic cell reprogramming. We identified a critical role for NAC1 in transcriptionally and post-transcriptionally modulating E-cadherin expression during the generation of iPSCs. In the absence of NAC1 functions, reprogramming is diverted to an anomalous state that can be fully rescued with the re-expression of Nac1.

ORGANISM(S): Mus musculus

PROVIDER: GSE100350 | GEO | 2017/10/04

SECONDARY ACCESSION(S): PRJNA391423

REPOSITORIES: GEO

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