Transcriptomics

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Gene Expression Profiling of SPOP Knocked Down Cell


ABSTRACT: SPOP is one of the most frequent mutated genes in prostate cancer. In the current study, we identified CCNE1 as its substrate. SPOP directly interacts with CCNE1, poly-ubiquitinates CCNE1 in vivo and in vitro, and represses cancer-related phenotypes induced by CCNE1 expression. Thus, we reveal a new mechanism for SPOP in repressing prostate cancer tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100743 | GEO | 2018/10/03

REPOSITORIES: GEO

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