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Omics analysis of transgenic chickens compared with non-transgenic chickens [genotypes]

ABSTRACT: To investigate food safety made from genetically modified organisms and genome editing organism, we researched the difference of the metabolic substances between wild type and transformant in chicken blood by using transcriptome, proteome and metabolome analysis. In this study, we compared the difference of gene expression between wild type and GFP hetero transformant in leukocyte extracted from 1-2 month old female chickens.

ORGANISM(S): Gallus gallus

PROVIDER: GSE100879 | GEO | 2017/07/07

SECONDARY ACCESSION(S): PRJNA393340

REPOSITORIES: GEO

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Omics analysis of transgenic chickens compared with non-transgenic chickens [gender]

Project description:To investigate food safety made from genetically modified organisms and genome editing organism, we researched the difference of the metabolic substances between wild type and transformant in chicken blood by using transcriptome, proteome and metabolome analysis. In this study, for the first basic research, we compared the difference of gene expression by sexual difference in leukocyte extracted from 1-2 month old wild type chickens.

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Omics analysis of transgenic chickens compared with non-transgenic chickens

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Project description:Beak deformities (BD) of different forms have been documented in many wild birds. The phenomenon is termed as “the largest epizootic of gross abnormalities ever recorded among wild bird populations.” Frequencies of 1% to 3% of BD (crossed beaks) were found in several indigenous chickens including Silkies, Qingyuan Partridge, Huxu, and the Beijing-You (BJY) chickens (studied here). Birds with deformed beaks have poor production performance and induce higher mortality. Therefore, BD represents an economic as well as a welfare problem. Our lab have focused and performed studies on this complex trait/disease for 7 years. Therefore, we performed a single SNP, a pathways-based genome-wide association study (GWAS), and a genome-wide CNV detection with the genotype data of 48 BD (case) and 48 normal (control) birds from Affymetrix 600K HD genotyping arrays, using ROADTRIPS, SNP ratio test (SRT) and PennCNV, respectively. To the best of our knowledge, this is the first GWAS and CNV study to investigate the mutations and genomic structural variations in the deformed and normal beaks of chickens. The findings herein are worth of further functional characterization for better understanding the genetic mechanisms of BD in chickens and wild birds as well.

2017-07-21 | GSE101703 | GEO

Transcription profiling of chickens exposed to chronic unpredictable light or predictable light and their offspring

Project description:A 14k cDNA microarray was used to examine gene expression difference in hypothalamus of chickens exposed to a chronic unpredictable light (UL) rhythm, in relation to chickens living under predictable light (PL). Offspring of UL and PL parents were thereafter compared in the same manner, with the only exception that both offspring groups lived under the PL treatment, hence investigating the effect of having a parent living under unpredictable light.

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Project description:Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain. C. jejuni is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in Campylobacter has become a concern for public health.To facilitate understanding the molecular basis associated with the fitness difference between Erys and Eryr Campylobacter, we compared the transcriptomes between ATCC 700819 and its isogenic Eryr transformant T.L.101 using DNA microarray. The design utilized an available two color microarray slide for the entire transcriptome of Campylobacter jejuni. Four hybridizations were performed each with independently extracted samples of either macrolide susceptible ATCC 700819 cDNA samples or its isogenic Eryr transformant T.L.101 cDNA samples. A dye swap was utilized to help minimize dye dependent bias. Thus, there were four biological replicates of each sample.

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