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Expression data from whole blood in CD patients undergoing HSCT.

ABSTRACT: Treatment of severely refractory Crohn’s disease (CD) patients remains a clinical challenge. Recent studies show efficacy of autologous hematopoietic stem cell transplant (HSCT) in these severely compromised patients. HSCT is thought to eliminate auto-reactive cells; however the mechanisms are incompletely understood. We followed a group of patients (n=18) receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanism driving efficacy we compared the immunological changes induced by HSCT in responders and non-responders.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100922 | GEO | 2019/01/23

REPOSITORIES: GEO

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Differences in tissue immune cell populations following hematopoietic stem cell transplantation in Crohn’s disease patients

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Recipient and donor expression differences in children treated with HSCT

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