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Differences in tissue immune cell populations following hematopoietic stem cell transplantation in Crohn’s disease patients

ABSTRACT: Treatment of severely refractory Crohn’s disease (CD) patients remains a clinical challenge. Recent studies show the efficacy of autologous hematopoietic stem cell transplant (HSCT) in these severely compromised patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available. We studied a group of CD patients receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanism driving efficacy, we studied changes in the immune cell composition in tissue induced by HSCT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE115390 | GEO | 2019/01/23

REPOSITORIES: GEO

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Differences in tissue populations following hematopoietic stem cell transplantation in Crohn’s disease patients

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