Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide maps of histone modifications in WT, Dnmt3a-/- and Tet1-/- J1 ES cells.

ABSTRACT: Using ChIP-seq to assess changes of histone modifications in response to Dnmt3a or Tet1 deficiency.

ORGANISM(S): Mus musculus

PROVIDER: GSE100953 | GEO | 2018/05/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-wide maps of histone modifications (SpikeIn) and Suz12 in WT, Dnmt3a-/-, Tet1-/- J1 and DKO ES cells.

Project description:Using ChIP-seq to assess changes of histone modifications in response to Dnmt3a or Tet1 deficiency.

2018-05-16 | GSE112311 | GEO

Genome-wide maps of Tet1 binding in [WT, Tet1-Flag] and [Dnmt3a-/-, Tet1-Flag] J1 ES cells

Project description:In order to assess Tet1 binding, we first generated a Flag tagged Tet1 ES cells and then knocked out Dnmt3a in the [WT, Tet1-Flag] cells. By Tet1 ChIP and Flag ChIP, we showed that Tet1 binding was complementary to Dnmt3a. And Tet1 binding was not affected or slightly increased at majority of its targets.

2018-05-16 | GSE100955 | GEO

Quantitative analysis of WT, Dnmt3a-/-, Dnmt3b-/- and Tet1-/- J1 ES cell transcriptomes

Project description:In order to figure out the roles of Dnmt3 and Tet1 in gene regulation, we assessed global gene expression changes in Dnmt3aKO, Dnmt3bKO and Tet1KO ES cells.

2018-05-16 | GSE100954 | GEO

Genome-wide maps of Dnmt3a1 binding in WT and Tet1-/- J1 ES cells

Project description:By biotin-streptavidin ChIP, we found that Dnmt3a1 enriched at diatal promoter regions and its binding was elevated by Tet1 deletion.

2018-05-16 | GSE100951 | GEO

Genome-wide maps of histone modifications (SpikeIn) and Suz12 in WT, Dnmt3a-/-, Tet1-/- J1 and DKO ES cells.

Project description:Genome-wide maps of histone modifications (SpikeIn) and Suz12 in WT, Dnmt3a-/-, Tet1-/- J1 and DKO ES cells.

| PRJNA445609 | ENA

DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors

Project description:To examine whether Dnmt3a deficiency resulted in genomic methylation changes we performed an unbiased methylome analysis. Methylated DNA isolated from three Dnmt3a deficient and two WT tumors was immunoprecipitated and subjected to high throughput sequencing (MeDIP-Seq). We observed that genes that were less expressed in Dnmt3a deficient tumors tended to have lower methylation levels in gene bodies. Examination of methylcytosine in two tumor types

2011-10-25 | E-GEOD-32484 | biostudies-arrayexpress

DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors

2011-10-26 | GSE32484 | GEO

Mouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT

Project description:Transcriptional profiling of mouse lung tumors comparing Dnmt3a KO/K-ras G12D mutant with Dnmt3a WT/K-ras G12D mutant. The goal is to search for the difference of mRNA abundance between Dnmt3a KO and WT tumors. Two-condition experiment, KO vs. WT tissure. Biological replicates: 12.

2011-10-25 | E-GEOD-32415 | biostudies-arrayexpress

The role of DNMT3A and TET1 in regulating promoter epigenetic landscapes

Project description:The role of DNMT3A and TET1 in regulating promoter epigenetic landscapes

| PRJNA393520 | ENA

Mouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT

2011-10-26 | GSE32415 | GEO