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Type I interferon gene expression response to chemotherapy

ABSTRACT: Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients by delaying distant relapses or inducing cure, but the mechanism is not fully clear. Here, we performed a gene expression analysis to demonstrate that estrogen-receptor (ER)-negative murine 4T1 mammary adenocarcinoma cells treated by chemotherapy in vitro activate the IFNß/IFNAR/IRF7 pathway to elicit a T cell-dependent immune response that maintains cancer cells in a dormant state in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE100973 | GEO | 2019/03/28

REPOSITORIES: GEO

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