Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Open Chromatin and HIF-binding in renal tubular cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101064 | GEO | 2017/07/11

SECONDARY ACCESSION(S): PRJNA393644

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Open chromatin, HIF binding and mRNA expression analysis in podocytes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-26 | GSE224538 | GEO

Multiomics analysis of HIF-stabilization in primary renal tubular cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-05 | GSE227849 | GEO

Open Chromatin and HIF-binding in renal tubular cells [FAIRE-seq]

Project description:Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of genetic signals on this pathway, we aligned human RCC-susceptibility polymorphisms with genome-wide assays of HIF-binding and observed highly significant overlap. Allele-specific assays of HIF binding, chromatin conformation and gene expression together with eQTL analyses in human tumors were applied to mechanistic analysis of one such overlapping site at chromosome 12p12.1. This defined a novel stage-specific mechanism in which the risk polymorphism, rs12814794, directly creates a new HIF-binding site that mediates HIF-1? isoform specific upregulation of its target BHLHE41. The alignment of multiple sites in the HIF cis-acting apparatus with RCC-susceptibility polymorphisms strongly supports a causal model in which minor variation in this pathway exerts significant effects on RCC development.

2017-07-11 | GSE101062 | GEO

Open Chromatin and HIF-binding in renal tubular cells [ChIP-seq]

2017-07-11 | GSE101063 | GEO

Open Chromatin and HIF-binding in renal tubular cells

Project description:Open Chromatin and HIF-binding in renal tubular cells

| PRJNA393644 | ENA

Genome-wide mapping of Hif-1Î± binding sites in zebrafish

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-22 | E-GEOD-70886 | biostudies-arrayexpress

Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-07 | E-GEOD-59783 | biostudies-arrayexpress