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Development of gene expression signatures for experimental lingual carcinogenesis

ABSTRACT: To identification of gene expression profiling during lingual tumorigenesis, tongue cancer was induced by oral delivery of 4-nitroquinoline-1-oxide (4NQO) at a dose of 50mg/L for 16weeks in C57BL/6J female mice. Nine samples of lingual mucosa from 0th (encoded as C in experiment), 12th ((encoded as M in experiment) and 28th ((encoded as E in experiment) week which were supposed as normality, early stage and cancer during lingual tumorigenesis were harvested for microarray. 2339, 2539 and 2482 genes were significantly varied between M vs. C, E vs. M and E vs. C respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE101469 | GEO | 2017/07/15

SECONDARY ACCESSION(S): PRJNA394518

REPOSITORIES: GEO

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