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Microtus fortis liver RNA-Seq during Schistosoma japonicum infection

ABSTRACT: The gogal of this study is to use RNA-Seq to systematically investigate the dynamics of the liver transcriptome over Schistosoma japonicum infection.

ORGANISM(S): Alexandromys fortis

PROVIDER: GSE101654 | GEO | 2020/10/15

REPOSITORIES: GEO

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Mice liver RNA-Seq during Schistosoma japonicum infection

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miRNAs expression in murine liver during Schistosoma japonicum infection

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Project description:Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at day 15, 30, and 45 post infection (pi) with that from uninfected mice as controls. Meanwhile, microRNA expression profiles from the same samples were decoded by parallel solexa sequencing. Gene expression alternation associated with liver damage was observed even at early stage of infection (e.g., pi 15), which became more magnificent onset of egg deposition within the liver tissue. Up-regulated genes were dominantly associated with inflammatory infiltration of liver during S. japonicum infection, whereas down-regulated genes primarily led to the hepatic functional disorders. More than 130 miRNAs were differentially expressed during S. japonicum infection, and dynamic miRNA-gene co-expression network has been constructed during the development of hepatic pathology.

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Project description:Schistosoma japonicum causes severe disease or even death and liver fibrosis is the major damage, which is caused by immunopathological injury. However, a comprehensive understanding of the immune cell changes during S. japonicum infection is lacking. Here, we performed single-cell RNA-sequencing and T/B cell receptor sequencing (scRNA-seq/scTCR-seq/scBCR-seq) of the total mouse splenocytes after cercaria infection.The changes of immune cells with advancing disease stages were analyzed and the relationship with liver fibrosis was investigated.

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Towards an understanding of the mechanism of hypoevolution of Schistosoma japonicum schistosomula from Microtus fortis

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Towards an understanding of the mechanism of hypoevolution of Schistosoma japonicum schistosomula from Microtus fortis

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