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Albendazole induces monocytic differentiation in AML cells through modulating KLF4-DPYSL2A axis

ABSTRACT: To compare the global gene expressions between KLF4-expressed AML cells and albendazole-treated AML cells, we conducted gene expression arrays in THP-1 cells lentivirally-transduced with doxycycline-inducible KLF4 or in THP-1 cells treated with albendazole in different concentrations. We identified that albendazole induces prominent differentiation in THP-1 cells through up-regulating KLF4 and DPYSL2A expressions. Considering the guaranteed safety and tolerability of albendazole in humans, this drug could easily be repositioned to AML patients once its anti-tumor efficacy is clarified.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101784 | GEO | 2021/03/09

REPOSITORIES: GEO

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