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TGF-b utilizes a novel receptor activation mechanism to phosphorylate SMAD1/5 and regulate epithelial-to-mesenchymal transition

ABSTRACT: TGF-b treatment leads to the transcriptional regulation of many genes. However, the proportion of those that are dependent on SMAD1/5 is unknown. Here, we compared the transcriptional profile after TGF-b treatment in a parental clone and one in which SMAD1/5 had been deleted by CRISPR/Cas9 to identify SMAD1/5 dependent genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE103372 | GEO | 2018/02/16

REPOSITORIES: GEO

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