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Control of brain tumor growth by reactivating monocytes and macrophages with niacin

ABSTRACT: We have found that innate immune cells (monocytes/macrophages) are compromised in malignant glioma, and we have determined that vitamin B3 (niacin) reactivates and/or reprograms monocytes/macrophages to inhibit glioma growth, particularly by suppressing the growth of brain tumor initiating cells (BTICs). To this end, we sought to obtain insights into the mechanisms by which niacin regulates monocyte/macrophage activity to alter glioma growth. Analysis of the microarray data identified several genes that were differentially altered in niacin-treated monocytes that could regulate BTIC growth. The study has identified a mechanistic basis for the regulation of glioma growth with niacin treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103381 | GEO | 2017/09/05

SECONDARY ACCESSION(S): PRJNA401840

REPOSITORIES: GEO

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