Transcriptomics

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CARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis


ABSTRACT: We investigated the role of PRMT4 in normal and malignant hematopoiesis. We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leukemia cell lines, identifying several mechanisms for the leukemia-specific dependence on PRMT4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103528 | GEO | 2018/06/10

REPOSITORIES: GEO

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