Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data of E12.5 Slc39a8 knockout (KO) embryo heart and wild type (WT) control

ABSTRACT: Slc39a8 KO mouse embryo hearts exhibit ventricle noncompaction phenotype which becomes evident at E12.5. The goal of this experiment is to identify genes that are differentially expressed between Slc39a8 KO and WT, which may be underlying the phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE103673 | GEO | 2017/10/10

SECONDARY ACCESSION(S): PRJNA404010

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome analyses of intestine-specific Slc39a8-KO mice

Project description:Purpose: To identify genes whose expression was altered in the intestinal epithelial cells (IECs) of Slc39a8-KO mice. Methods: Poly(A) RNA-seq Results: We identified four genes that showed changes in their expression in the Slc39a8-KO IECs.

2024-04-05 | GSE192695 | GEO

Neuronal SLC39A8 deficiency impairs cerebellar development and function by dysregulating brain Mn homeostasis

Project description:RNAseq was performed using cerebellum tissue of WT and neuron-specific slc39a8-KO mice

2024-08-01 | GSE217704 | GEO

Transcriptome analyses of intestine-specific Slc39a8-KO mice

Project description:Transcriptome analyses of intestine-specific Slc39a8-KO mice

| PRJNA792728 | ENA

RNA-seq analysis of Slc39a8(neo/neo) versus wild-type mice: yolk sac, placenta and fetal liver, kidney, lung, heart and cerebellum

Project description:Slc39a8 encodes ZIP8, a ubiquitous divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cell; ZIP8 influxes Zn2+, Mn2+ and Fe2+. Slc39a8(neo/neo) knockdown mice globally exhibit 10-15% of wild-type ZIP8 mRNA and protein levels, and show a pleiotropic phenotype of stunted growth, neonatal lethality, multi-organ dysmorphogenesis, and dysregulated hematopoiesis manifested as severe anemia. Herein we performed transcriptomics of GD13.5 yolk sac and placenta, and GD16.5 liver, kidney, lung, heart and cerebellum, comparing Slc39a8(neo/neo) with wild-type. Meta-data analysis of differentially-expressed genes revealed 29 unique genes from all tissues –– having enriched GO categories associated with hematopoiesis and hypoxia and KEGG categories of complement, response to infection, and the coagulation cascade –– consistent with dysregulated hematopoietic stem cell fate. Based on transcription factor (TF) profiles in the JASPAR database, and searching for TF-binding sites enriched by Pscan, numerous genes encoding zinc-finger TFs and associated with hematopoietic stem cell functions were identified. We conclude that, in this mouse model, deficient ZIP8-mediated Zn2+ transport affects zinc-finger (e.g. GATA proteins) and other transcription-factors (e.g. TAL1) predominantly in yolk sac, strongly supporting the observed dysmorphogenesis and anemia phenotype.

2018-07-01 | GSE111080 | GEO

The schizophrenia-associated variant in SLC39A8 alters N-glycosylation in the mouse brain

Project description:In this experiment we performed RNAseq from two different bran regions of wild-type and mice containing the A391T missense mutation in SLC39A8.

2021-09-23 | GSE184516 | GEO

Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

Project description:Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the zinc transporter ZIP8 (SLC39A8) protein. In this study, we have attempted to explore the effects of ZIP8 overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

2017-10-10 | GSE104795 | GEO

AP-2α pull down from E12.5 cortex

Project description:Identificatin of interaction partners of AP-2α via pull down from the cortex of E12.5 mice followed by quantitative mass spectrometry.

2023-12-11 | PXD047202 | Pride

RNA-Seq on E12.5 WT and LncBAR-KO (KO) neurospheres (passage 3)

Project description:RNA-Seq on E12.5 WT and LncBAR-KO (KO) neurospheres (passage 3)

| PRJNA715465 | ENA

Mus musculus

Project description:Expression data of E12.5 Slc39a8 knockout (KO) embryo heart and wild type (WT) control

| PRJNA404010 | ENA

BRG1 ChIP-Seq on E12.5 WT and LncBAR-KO (KO) neurospheres (passage 3)

Project description:BRG1 ChIP-Seq on E12.5 WT and LncBAR-KO (KO) neurospheres (passage 3)

| PRJNA715466 | ENA