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ChIP-chip from HCT116 cells with UbH2B and H3K4me2 coupled to expression analysis

ABSTRACT: Histone H2B monoubiquitylation has been implicated in transcription. We generated anti-UbH2B antibodies and applied these antibodies in ChIP-chip experiments revealing preferential association of ubiquitylated H2B with the transcribed regions of highly expressed genes. Unlike dimethylated H3K4, UbH2B was not associated with distal promoter regions. Keywords: Chip-chip, Expression analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE10453 | GEO | 2008/02/12

SECONDARY ACCESSION(S): PRJNA108007

REPOSITORIES: GEO

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Co-transcriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

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