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Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation [RNA-seq]

ABSTRACT: Comparison of the meis2b+ and the meis2b- halves of the atrium of the adult zebrafish atrium reveals the existence of two different transcriptional domains. These two domains analogous to that of the two atria in terrestrial vertebrates

ORGANISM(S): Danio rerio

PROVIDER: GSE104573 | GEO | 2018/05/09

REPOSITORIES: GEO

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Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation II

Project description:For the study of possible downstream targets of Meis2b, we compared the following expression profiles: 48hpf whole larvae of meis2bs988/s988 to meis2b+/+ siblings, whole heart of 3 wpf meis2bs988/s988 to meis2b+/s988 siblings, atria of 3 mpf meis2bs988/s988 to meis2bs988/+ siblings, and ventricle to atrium of 3 mpf WT zebrafish.

2018-05-09 | GSE94491 | GEO

Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-09 | GSE94492 | GEO

Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation I

Project description:Comparison of total RNA of atrial and ventricular chambers from adult zebrafish heart. The goal was to identify chamber specific transcripts and atrial enriched transcripts that can be linked to atrial or ventricular septal defects in mammals.

2018-05-09 | GSE94490 | GEO

Genome-wide analysis of atrial left-right differences in two different mouse strains

Project description:Two wild-type mouse strains (Swiss Agouti and MF1) were investigated regarding the mRNA expression patterns of their left and right atria at 12 months of age. Eight samples of each strain, four with left atrium and four with right atrium examined.

2011-12-31 | E-GEOD-29500 | biostudies-arrayexpress

Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation

Project description:Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation

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Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation [RNA-seq]

Project description:Atrial Molecular Asymmetry Precedes the Emergence of Cardiac Septation [RNA-seq]

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Transcriptional profiling of the peri-pulmonary vein region of the adult mouse left atrium and corresponding Tbx5-dependence

Project description:The left atrium consists of three major parts: the peri-pulmonary vein portion, the appendage, and the vestibule. Previous transcriptional profiling of the adult left atrium and identification of the Tbx5-dependent transcriptome has focused on the atrial appendage (Nadadur et al 2016, Science Translational Medicine). In that study, Tbx5 was shown to regulate a gene regulatory network of atrial identity in the appendage and in its absence results in atrial fibrillation. In order to investigate the regional differences in the transcriptome of the left atrium, the left atrial appendage and the peri-pulmonary vein portion from adult mice were compared by RNA-sequencing. Additionally, as Tbx5 is major regulator of atrial identity, the peri-pulmonary vein portion of the atria was likewise examined following removal of Tbx5 using an adult specific conditional knockout of Tbx5.

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The full cardiac G protein-coupled receptor repertoire reveals chamber-specific expression patterns

Project description:Cardiac function is regulated by many hormones and neurotransmitters which exert their physiological effects through the activation of G protein-coupled receptors (GPCRs). Here, we quantified the expression of 395 endoGPCRs (all GPCRs excluding taste and odorant receptors) in male mouse right and left atria and ventricles by using high-throughput real-time RT-PCR and focused on the 135 most highly expressed transcripts. No cardiac functional data is available for almost half of these receptors. Cluster analysis allowed us to link GPCR expression patterns to cardiac function. Indeed, ventricles and atria are both contractile; however, the latter, and especially the right atrium, are central to the generation and regulation of cardiac rhythm. Accordingly, the right atrium exhibited the most specific signature whereas the vast majority of GPCRs found in ventricles were evenly expressed in both the right and left chambers. RT-PCR data were confirmed at the protein level for six selected transcripts (ETA, EP1, PAR1, Sfrp1, CCR2 and AT1a) and at the functional level in isolated mouse ventricular cardiomyocytes for the glutamate metabotropic receptor 1b.

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Atrial fibrillation is associated with altered left-to-right atria gene expression ratio: implications for arrhythmogenesis and thrombogenesis

Project description:Background: Atrial fibrillation (AF) causes atrial remodeling, and the left atrium (LA) is the favored substrate for maintaining AF. However, it remains unclear if AF remodels both atria differently and contributes to LA arrhythmogenesis and thrombogenesis. Results: AF was associated with differential LA-to-RA gene expression related to specific ion channels and pathways as well as upregulation of thrombogenesis-related genes in the LA appendage. Targeting the molecular mechanisms underlying the LA-to-RA difference and AF-related remodeling in the LA appendage may help provide new therapeutic options in treating AF and preventing thromboembolism in AF. Paired left atrial and right atrial specimens were obtained from 13 patients with persistent AF receiving valvular surgery. The Paired specimens were sent for microarray comparison. Selected results were validated by quantitative real time-PCR (q-PCR) and Western blotting. Ultrastructural changes in the atria were evaluated by immunohistochemistry.

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Global gene expression changes in E9.5 cardiopharyngeal mesoderm (CPM) of Chd7 mutants versus controls

Project description:To investigate the role of Chd7 in the CPM we performed RNA-seq on two microdissections from Mesp1-Cre; Chd7 fl/fl (referred to as cKO) and control (Mesp1-Cre) embryos. The first involved the distal pharyngeal apparatus, i.e. arches two through six including the dorsal pericardial wall (DPW) which encompasses the SHF before these cells migrate to the poles of heart. For simplicity we refer to this dissection as “SHF” (we use inverted commas in this denotation to recognise the presence of other cell types). The second microdissection included the cells that have entered the heart (i.e. SHF-derived outflow tract (OFT), right ventricle (RV) and parts of the atrium, and FHF-derived left ventricle and atria). The OFT and heart tissue was collected from the same embryos (labelled “HEART”).

2023-04-29 | GSE229629 | GEO

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