Genomics

Dataset Information

0

Role of histone demethylase Kdm6a in pancreatic cancer - ChIP-Seq


ABSTRACT: Loss-of-function mutations of KDM6A, an X chromosome encoded histone H3K27 demethylase, are frequent in a broad spectrum of epithelial and hematopoietic malignancies and contribute to oncogenesis with so far poorly characterized mechanisms. Pancreas specific ablation of Kdm6a in mice accelerated Kras-driven cell transformation and compromised survival in a gender specific manner. Female knockout animals were particularly vulnerable and developed aggressive squamous and quasi-mesenchymal tumors with metastatic potential, as opposed to the males which developed adenocarcinomas and exhibited a better prognosis. Integration of gene expression studies coupled to ChIP-seq profiling of chromatin modifications demonstrated that loss of Kdm6a caused genome-wide remodeling of bivalent promoters and rewiring of enhancer chromatin to repress endodermal fate by activating c-MYC and TP63 dependent transcriptional programs favoring squamous and quasi-mesenchymal differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE104739 | GEO | 2018/04/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-04-01 | GSE98568 | GEO
2018-04-01 | GSE98066 | GEO
2018-04-01 | GSE98065 | GEO
2013-03-22 | E-GEOD-45390 | biostudies-arrayexpress
2017-03-01 | GSE92723 | GEO
2024-01-28 | PXD041254 | Pride
2024-10-01 | GSE244510 | GEO
2023-03-03 | GSE216625 | GEO
2024-06-30 | GSE263236 | GEO
2022-07-20 | GSE155630 | GEO