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Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE104811 | GEO | 2018/10/10

REPOSITORIES: GEO

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Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Mechanistically, loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

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Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

2018-10-10 | GSE104809 | GEO

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

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Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

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Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

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