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Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

ABSTRACT: Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

PROVIDER: PRJNA413915 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6158152.fastq.gz	Fastqsanger.gz
	SRR6158153.fastq.gz	Fastqsanger.gz
	SRR6158154.fastq.gz	Fastqsanger.gz
	SRR6158155.fastq.gz	Fastqsanger.gz
	SRR6158156_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

| PRJNA413925 | ENA

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

| PRJNA413924 | ENA

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Mechanistically, loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

2018-10-10 | GSE104810 | GEO

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

2018-10-10 | GSE104809 | GEO

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-10 | GSE104811 | GEO

Expression profiling of ethanol-treated and EPZ5676-treated mouse DBA2 SSCs

Project description:We repport the effect of EPZ5676 (DOT1L inhibiotr) on the transcriptome of cultured mouse DBA2 spermatogonial stem cells (SSCs). SSCs were cultured in the presence of 2 uM EPZ5676 or 0.2% ethanol (control) for 2 weeks. We find a number of differentially expressed genes between control and EPZ5676-treated SSCs.

2022-07-26 | GSE181590 | GEO

Lung lymphatic endothelial cells

Project description:Lung lymphatic endothelial cells

| PRJNA882358 | ENA

Lymphatic endothelial cells comparison gene array data

Project description:GeneChipÂ® Mouse Gene 2.0 ST Array for C57BL/6 mouse skin dermal primary lymphatic endothelial cells (Ms LEC) and mouse lymphatic endothelial cell line SVEC4-10 GeneChipÂ® Human Gene 2.0 ST Array for human primary lymphatic endothelial cells (Hu LEC) Total RNA from lymphatic cell line SVEC4-10 were used for GeneChipÂ® Mouse Gene 2.0 ST Array. SVEC4-10 samples, human and mouse LEC samples.

2016-07-20 | E-GEOD-84551 | biostudies-arrayexpress

Expression data from vehicle and adrenomedullin treated human lymphatic endothelial cells

Project description:Human dermal lymphatic endothelial cells were cultured and treated with either vehicle or 10 nM AM for 15 minutes, 1 hour, or 24 hours to assess gene expression changes across the human genome with AM treatment. Two variable experiment, time (0.25, 1, 24 hours) and treament (vehicle vs adrenomedullin) of gene expression in human lymphatic endothelial cells. Biological replicates: 3-4 per condition.

2014-07-31 | E-GEOD-59938 | biostudies-arrayexpress

Lymphatic endothelial cells comparison gene array data

Project description:GeneChip® Mouse Gene 2.0 ST Array for C57BL/6 mouse skin dermal primary lymphatic endothelial cells (Ms LEC) and mouse lymphatic endothelial cell line SVEC4-10 GeneChip® Human Gene 2.0 ST Array for human primary lymphatic endothelial cells (Hu LEC) Total RNA from lymphatic cell line SVEC4-10 were used for GeneChip® Mouse Gene 2.0 ST Array.

2016-07-20 | GSE84551 | GEO

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