Targeting Macrophages that Form a Chemotherapy-induced Niche Significantly Reduces Cancer Stem Cells and Tumors
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ABSTRACT: Failure in cancer therapy is often caused by relapse resulting largely from chemo-resistant cancer stem cells (CSCs). Most colorectal cancer patients, after receiving chemo- or chemoradiotherapy, still harbor treatment-resistant residual tumor cells that are akin to colorectal adenoma. We therefore chose the APCMin adenoma model that allowed us to study the natural and dynamic interaction between CSCs and their microenvironment in vivo following therapeutic stress.
ORGANISM(S): Mus musculus
PROVIDER: GSE106132 | GEO | 2025/01/01
REPOSITORIES: GEO
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