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Individual array-based gene expression patterns generated using total RNA prepared from whole blood of 991 participants of the SHIP-TREND cohort

ABSTRACT: The data set comprises individual array-based genome-wide gene expression data of 991 participants of the SHIP-TREND cohort generated using RNA prepared from whole blood. *** Due to privacy concerns, the SNP and phenotype data is not available with unrestricted access. Individuals wishing to obtain this data for research purposes may request access directly from the submitter (contact info below). *** Total RNA was prepared from whole-blood samples from 991 individuals belonging to the epidemiological SHIP-TREND cohort. Individual mRNA profiles were generated using the Illumina HumanHT-12 v3 Expression BeadChip.

ORGANISM(S): Homo sapiens

SUBMITTER: Uwe Völker 

PROVIDER: E-GEOD-36382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Importance</h4>Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H. pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H. pylori susceptibility.<h4>Objective</h4>To identify genetic loci associated with H. pylori seroprevalence in 2 independent population-based cohorts and to determine their putative pathophy  ...[more]

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