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Multi-axial self-organisation properties of mouse embryonic stem cells into gastruloids [bulk]

ABSTRACT: Gastruloids are small aggregates of murine Embryonic Stem (ES) cells stimulated to undergo gastrulation-like symmetry breaking events in vitro (van den Brink, S. C. et al. 2014, Simunovic, M. & Brivanlou, A. H 2017). We analyzed the transcriptomic profiles of gastruloids at different time-points after aggregation (AA), showing that they are capable of organizing a post-occipital pattern of neural, mesodermal and endodermal derivatives that mimics that of the embryo in terms of gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE106225 | GEO | 2018/06/01

REPOSITORIES: GEO

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