Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transfer RNA Genes Affect Chromosome Architecture and Function

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE106250 | GEO | 2019/03/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transfer RNA Genes Affect Chromosome Architecture and Function

Project description:In this study we investigated the role of tDNAs in genomic organization and nuclear function by editing a chromosome so that it lacks any tDNAs.

2019-03-06 | GSE98304 | GEO

Transfer RNA Genes Affect Chromosome Architecture and Function

Project description:Chromosomes are packaged and organized in the nucleus in an ordered, non-random manner. This organization influences many nuclear processes such as transcription, gene silencing and mitosis. While transfer RNA genes (tDNAs) are essential for the generation of tRNAs these gene loci are also binding sites for transcription factors and chromosomal architectural proteins. In the yeast Saccharomyces cerevisiae, tDNAs are dispersed along all sixteen chromosomes. In this study, we investigated the role of tDNAs in genomic organization and nuclear function by editing a chromosome so that it lacks any tDNAs. Our analyses of this tDNA-less chromosome show that loss of tDNAs affect nucleosome positioning, binding of SMC proteins, centromere clustering, long-range chromosome folding and epigenetic gene silencing. We propose that these effects are primarily mediated via changes in local interactions between tDNAs and other regulatory sequences that then manifest as alterations in long-range chromosome architecture with effects on gene regulation over large distances.

2017-10-30 | GSE98543 | GEO

Transfer RNA Genes Affect Chromosome Architecture and Function [ChIP-seq]

Project description:In this study, we investigated the role of tranfer RNA genes (tDNAs) in genome organization and nuclear function by generating a chromosome lacking all its tDNAs. Our analyses of this tDNA-less chromosome show that loss of these genes affects nucleosome postioning, SMC protein binding, centromere clustering, long range chromosome folding and epigenetic silencing.

2019-03-05 | GSE106249 | GEO

Transfer RNA Genes Affect Chromosome Architecture and Function [RNA-seq]

2019-03-05 | GSE106248 | GEO

Transfer RNA Genes Affect Chromosome Architecture and Function

Project description:Transfer RNA Genes Affect Chromosome Architecture and Function

| PRJNA415991 | ENA

Induced genomic rearrangements and chromothripsis by micronucleus-mediated chromosome transfer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-13 | E-GEOD-71979 | biostudies-arrayexpress

Cohesin is a key determinant of interphase chromosome domain architecture

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-11 | E-GEOD-49018 | biostudies-arrayexpress

Transfer RNA Genes Affect Chromosome Architecture and Function [RNA-seq]

Project description:Transfer RNA Genes Affect Chromosome Architecture and Function [RNA-seq]

| PRJNA415993 | ENA

Transfer RNA Genes Affect Chromosome Architecture and Function [ChIP-seq]

Project description:Transfer RNA Genes Affect Chromosome Architecture and Function [ChIP-seq]

| PRJNA415992 | ENA

Induced genomic rearrangements and chromothripsis by micronucleus-mediated chromosome transfer

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-13 | GSE71979 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data