The HIV co-receptor CCR5, regulates the cellular architecture of osteoclast
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ABSTRACT: C-C chemokine receptor 5 (CCR5) is a co-receptor of HIV. Its ligand, CCL5 significantly augmented the number of wild-type osteoclasts but not Ccr5-deficient cells, indicating that CCL5 enhanced RANKL-induced osteoclastogenesis through CCR5. To investigate the changes in the transcriptional signatures induced by CCL5 in osteoclastogenesis, cultured osteoclasts at pOC stages were incubated with or without rmCCL5 for 2 days, and then subjected for RNA sequencing.
ORGANISM(S): Mus musculus
PROVIDER: GSE106259 | GEO | 2017/11/15
SECONDARY ACCESSION(S): PRJNA416058
REPOSITORIES: GEO
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