Transcriptomics

Dataset Information

0

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies


ABSTRACT: Under various pathophysiological muscle-wasting conditions like diabetes and starvation, a family of ubiquitin ligases, including MuRF1 (Muscle specific RING-Finger protein 1), are induced to target muscle proteins for degradation via ubiquitination. In an attempt to identify the in vivo targets of MuRF1 we have generated transgenic mouse lines overexpressing MuRF1 in a skeletal muscle specific fashion. MuRF1-TG lines were viable and had normal fertility. Characterization of their skeletal muscles did not reveal evidence for muscle wasting at 10 weeks of age. In this experiment we compared the skeletal muscle transcriptome of transgenic mice with wildtypes. Keywords: MuRF1 transgene overexpression

ORGANISM(S): Mus musculus

PROVIDER: GSE10626 | GEO | 2008/05/15

SECONDARY ACCESSION(S): PRJNA107691

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-05-15 | PXD039158 | Pride
2023-05-15 | PXD039151 | Pride
2021-07-07 | PXD023872 | Pride
2021-12-01 | GSE179163 | GEO
2019-01-05 | GSE108940 | GEO
2021-11-23 | E-MTAB-11094 | biostudies-arrayexpress
2008-03-01 | E-MEXP-1027 | biostudies-arrayexpress
2009-06-03 | GSE11661 | GEO
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
2013-04-01 | GSE14512 | GEO