Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Tibialis Anterior
SUBMITTER: Delphi Van Haver
LAB HEAD: Sue Bodine
PROVIDER: PXD023872 | Pride | 2021-07-07
REPOSITORIES: Pride
Items per page: 1 - 5 of 18 |
Function (Oxford, England) 20210519 4
MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy. In this study, we used in vivo electroporation to determine whether MuRF1 overexpression alone can cause muscle atrophy and, in combination with ubiquitin proteomics, identify the endogenous MuRF1 substrates in skeletal muscle. Overexpressi ...[more]