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Role of Chromogranin A on renal function in a mouse model of failing kidney

ABSTRACT: Chromogranin A (CHGA) is elevated in plasma of patients with renal failure and several CHGA polymorphisms are associated with hypertensive renal disease. Therefore, we investigated the role of CHGA in kidney disease using the partial nephrectomy model of kidney failure. Mice under surgery to remove 2/3rds of the left kidney and the entire right kidney. Control mice received the sham surgery. Wild-type and CHGA-/- mice used. To model the changes in vitro, CRL-1927 kidney cells were treated with or without CHGA in vitro.

ORGANISM(S): Mus musculus

PROVIDER: GSE106300 | GEO | 2018/10/25

REPOSITORIES: GEO

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Role of Chromogranin A on renal function in a mouse model of failing kidney

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