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Low affinity TCRs support regulatory T cell function in autoimmunity

ABSTRACT: Low affinity Tregs are important for controlling autoimmune diabetes.

ORGANISM(S): Mus musculus

PROVIDER: GSE106467 | GEO | 2017/12/29

SECONDARY ACCESSION(S): PRJNA416932

REPOSITORIES: GEO

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Low affinity TCRs support regulatory T cell function in autoimmunity

Project description:Low affinity TCRs support regulatory T cell function in autoimmunity

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Project description:Recent findings suggest that undifferentiated, stem-like, antigen specific T cells serve as an important long-term reservoir for autoimmune CD8 T cell responses. However, it is still unclear whether CD4 T cells exhibit a similar differentiation trajectory culminating in terminal differentiation, acquisition of an exhausted phenotype, and loss of stemness and function. We analyzed islet infiltrating T cells by scRNAseq and flow cytometry and found that while CD4 T cells in autoimmune diabetes share many features of exhaustion with CD8 T cells, expression patterns of inhibitory receptors are distinct in autoimmune T cells compared to T cells in chronic LCMV infection.

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