To compare the transcriptome of ompR null strains with wild-type strain of S. Typhimurium during osmotic stress
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ABSTRACT: In bacteria, one paradigm for signal transduction is the two-component regulatory system, consisting of a sensor kinase (usually a membrane protein) and a response regulator (usually a membrane protein) and a response regulator (usually a DNA binding protein). The EnvZ/OmpR two-component system in S. Typhimurium responds to osmotic stress and regulates expression of outer membrane proteins. Furthermore, bacteria were believed to regulate pH by acidifying after external acid stress, then immediately recovering. Using a pH-sensor in single living cells, we show that S. Typhimurium maintain an acidic cytoplasm under sucrose-driven osmotic stress which requires OmpR. Thus, we set out to identify the OmpR targets of S. Typhimurium under osmotic stress.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
PROVIDER: GSE106629 | GEO | 2017/11/08
SECONDARY ACCESSION(S): PRJNA417483
REPOSITORIES: GEO
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